Restless legs syndrome is a common feature of adult celiac disease
Identifieur interne : 001A35 ( Main/Exploration ); précédent : 001A34; suivant : 001A36Restless legs syndrome is a common feature of adult celiac disease
Auteurs : Marcello Moccia [Italie] ; Maria Teresa Pellecchia [Italie] ; Roberto Erro [Italie] ; Fabiana Zingone [Italie] ; Sara Marelli [Italie] ; Damiano Giuseppe Barone [Italie] ; Carolina Ciacci [Italie] ; Luigi Ferini Strambi [Italie] ; Paolo Barone [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-05-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Celiac Disease (diet therapy), Celiac Disease (epidemiology), Coeliac disease, Comorbidity, Diet, Gluten-Free, Female, Humans, Male, Nervous system diseases, Prevalence, Restless Legs Syndrome (epidemiology), Restless legs syndrome, Sleep disorder, celiac disease, restless legs syndrome, sleep disorders.
- MESH :
- diet therapy : Celiac Disease.
- epidemiology : Celiac Disease, Restless Legs Syndrome.
- Adult, Comorbidity, Diet, Gluten-Free, Female, Humans, Male, Prevalence.
Abstract
Restless legs syndrome (RLS) is a common neurological condition, frequently idiopathic, sometimes associated with specific disorders such as iron deficiency. We investigated RLS prevalence in celiac disease (CD), an autoimmune disease characterized by several features such as malabsorption‐related iron deficiency anemia and peripheral neuropathy. We screened a population of 100 adult CD patients for CD features, iron metabolism, clinical and neurological conditions, and enrolled 100 age‐ and sex‐matched controls in the general population. RLS was ascertained in CD patients and controls by both the presence of the four essential International RLS Study Group diagnostic criteria and neurological examination. The International RLS Study Group rating scale was used to measure RLS severity. We found a 31% prevalence of RLS in the CD population that was significantly higher than the prevalence in the control population (4%; P < 0.001). The average severity of RLS in CD population was moderate (17 ± 6.5). In the CD population, no significant correlation was found between RLS and either gluten‐free diet or iron metabolism, despite hemoglobin levels were significantly lower in CD patients with RLS than without RLS (P = 0.003). We found no correlation between RLS and other possible causes of secondary RLS, including signs of peripheral neuropathy, pregnancy, end‐stage renal disease, and pharmacological treatments.Our study broadens the spectrum of neurological disorders associated with CD and indicates that RLS should be sought for in all patients with CD. © 2010 Movement Disorder Society
Url:
DOI: 10.1002/mds.22903
Affiliations:
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level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-05-15">2010-05-15</date><biblScope unit="vol">25</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="877">877</biblScope><biblScope unit="page" to="881">881</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">023298FEECBEBAD55BCC6FB3A5F776F0EC2388EE</idno><idno type="DOI">10.1002/mds.22903</idno><idno type="ArticleID">MDS22903</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Celiac Disease (diet therapy)</term><term>Celiac Disease (epidemiology)</term><term>Coeliac disease</term><term>Comorbidity</term><term>Diet, Gluten-Free</term><term>Female</term><term>Humans</term><term>Male</term><term>Nervous system diseases</term><term>Prevalence</term><term>Restless Legs Syndrome (epidemiology)</term><term>Restless legs syndrome</term><term>Sleep disorder</term><term>celiac disease</term><term>restless legs syndrome</term><term>sleep disorders</term></keywords><keywords scheme="MESH" qualifier="diet therapy" xml:lang="en"><term>Celiac Disease</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Celiac Disease</term><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Comorbidity</term><term>Diet, Gluten-Free</term><term>Female</term><term>Humans</term><term>Male</term><term>Prevalence</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie coeliaque</term><term>Pathologie du système nerveux</term><term>Syndrome des jambes sans repos</term><term>Trouble du sommeil</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Restless legs syndrome (RLS) is a common neurological condition, frequently idiopathic, sometimes associated with specific disorders such as iron deficiency. We investigated RLS prevalence in celiac disease (CD), an autoimmune disease characterized by several features such as malabsorption‐related iron deficiency anemia and peripheral neuropathy. We screened a population of 100 adult CD patients for CD features, iron metabolism, clinical and neurological conditions, and enrolled 100 age‐ and sex‐matched controls in the general population. RLS was ascertained in CD patients and controls by both the presence of the four essential International RLS Study Group diagnostic criteria and neurological examination. The International RLS Study Group rating scale was used to measure RLS severity. We found a 31% prevalence of RLS in the CD population that was significantly higher than the prevalence in the control population (4%; P < 0.001). The average severity of RLS in CD population was moderate (17 ± 6.5). In the CD population, no significant correlation was found between RLS and either gluten‐free diet or iron metabolism, despite hemoglobin levels were significantly lower in CD patients with RLS than without RLS (P = 0.003). We found no correlation between RLS and other possible causes of secondary RLS, including signs of peripheral neuropathy, pregnancy, end‐stage renal disease, and pharmacological treatments.Our study broadens the spectrum of neurological disorders associated with CD and indicates that RLS should be sought for in all patients with CD. © 2010 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Italie</li></country><region><li>Lombardie</li></region><settlement><li>Milan</li></settlement></list><tree><country name="Italie"><noRegion><name sortKey="Moccia, Marcello" sort="Moccia, Marcello" uniqKey="Moccia M" first="Marcello" last="Moccia">Marcello Moccia</name></noRegion><name sortKey="Barone, Damiano Giuseppe" sort="Barone, Damiano Giuseppe" uniqKey="Barone D" first="Damiano Giuseppe" last="Barone">Damiano Giuseppe Barone</name><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name><name sortKey="Ciacci, Carolina" sort="Ciacci, Carolina" uniqKey="Ciacci C" first="Carolina" last="Ciacci">Carolina Ciacci</name><name sortKey="Erro, Roberto" sort="Erro, Roberto" uniqKey="Erro R" first="Roberto" last="Erro">Roberto Erro</name><name sortKey="Marelli, Sara" sort="Marelli, Sara" uniqKey="Marelli S" first="Sara" last="Marelli">Sara Marelli</name><name sortKey="Pellecchia, Maria Teresa" sort="Pellecchia, Maria Teresa" uniqKey="Pellecchia M" first="Maria Teresa" last="Pellecchia">Maria Teresa Pellecchia</name><name sortKey="Strambi, Luigi Ferini" sort="Strambi, Luigi Ferini" uniqKey="Strambi L" first="Luigi Ferini" last="Strambi">Luigi Ferini Strambi</name><name sortKey="Zingone, Fabiana" sort="Zingone, Fabiana" uniqKey="Zingone F" first="Fabiana" last="Zingone">Fabiana Zingone</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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